Which statement is NOT correct concerning 2,3-bisphosphoglycerate (BPG) ?

A. It is an allosteric modulator.

B. It binds with lower affinity to fetal hemoglobin than to adult hemoglobin.

C. It binds at a distance from the heme groups of hemoglobin.

D. It is normally found associated with the hemoglobin extracted from red blood cells.

E. It increases the affinity of hemoglobin for oxygen.

E. It increases the affinity of hemoglobin for oxygen.

Explanation:

2,3-bisphosphoglycerate is a acid This is three carbon isomer of glycolytic.

The important about 2,3-bisphosphoglycerate

1. 2,3-bisphosphoglycerate binds at a distance from the heme groups of hemoglobin.

2. 2,3-bisphosphoglycerate is an allosteric modulator.

3. 2,3-bisphosphoglycerate is normally found associated with the hemoglobin extracted from red blood cells.

4. 2,3-bisphosphoglycerate binds with lower affinity to fetal hemoglobin than to adult hemoglobin.

So the option E is correct.