A deficiency in thiamine (TPP) will directly decrease the activity of which of the following enzymes? a. Pyruvate carboxylase b. Glucose 6-phosphate dehydrogenase c. Aldolase Bd. Transketolase

d. Transketolase

Explanation:

Transketolase utilize thiamine diphosphate (ThDP) as cofactor has reduced activity during the thiamine deficiency and results in the tissue damage. The levels of steady-state mRNA of transketolase in human lymphoblasts, fibroblasts and neuroblastoma cells are found to be lower in the thiamine-deficient cultures.

Thus, deficiency in TPP directly decrease the activity of enzyme, transketolase.