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8 September, 05:55

The first mechanistic step in the direct reaction of an amine with a carboxylic acid to produce an amide is:

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  1. 8 September, 07:11
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    Answer:-

    The first step involves protonation of the carbonyl carbon followed by attack of the Nitrogen of amine on it.

    Subsequently a water molecule is lost resulting in amide formation.
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