The first mechanistic step in the direct reaction of an amine with a carboxylic acid to produce an amide is:

Question

Chemistry

Andres Weber

8 September, 05:55

The first mechanistic step in the direct reaction of an amine with a carboxylic acid to produce an amide is:

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Madelyn Gould · Answer 1

Answer:-

The first step involves protonation of the carbonyl carbon followed by attack of the Nitrogen of amine on it.

Subsequently a water molecule is lost resulting in amide formation.