What is the significance of the title of the novel?

451 is the temperature at which paper burns.

There are 451 people who lose their life in the novel.

451 is the name of the district in which Guy Montag lives.

451 Fahrenheit is the main character's address.

Description

I'm pretty sure it's the first one. 451 degrees is the temp which paper burns, the book is about book burning. There aren't 451 characters that are focused on, I don't think 451 pertains to the address or district ... it was really vague to make it seem like it could happen anywhere to anyone.