A comma

(A) cannot be used to correct most run-on sentences

(B) can be used to correct most run-on sentences

(C) can be used to combine two independent clauses correctly

(D) is required to combine two dependent clauses correctly

A comma might be used to combine two independent clauses correctly (option C). it is called a comma splice in a run-on sentence. Por example: "you can leave your study at any time, you only need to indicate your preference."

It is very important to clarify that a run-on sentence is made up for two or more independent clauses connected improperly.