In what ways do you think the Missouri Compromise and the nullification crisis of 1832 might be considered important milestones in American history?

Both the Missouri Compromise and The Nullification Crisis of 1832 were two triggers (the first direct and the second indirect) for the American Civil War, as it faced states with slaves against the government of North (in the case of the Missouri Compromise), which attacked the southern economy, and manifested the sectionism between North and South. In the case of The Nullification Crisis of 1832, the North "attacked" North Carolina in terms of its tariffs, and manifested the weakness of the South, as opposed to the union of the North. Both events were the precursors of the Civil War of America.