Which of these was a negative result of the construction of the panama canal?

Officially recognized as the one of the seven wonders of the modern world by the American Society of Civil Engineers, the Panama Canal was and still is one of the biggest and hardest engineering feats ever accomplished. It greatly reduced the time necessary to get from the Atlantic to Pacific Ocean but unfortunately it also led to the resentment of various Latin countries including Columbia towards the US because of the role US played in the conflict between Panama and Columbia.