What Romans 3:16 mean?

Romans 3:16 is Destruction and misery are in their ways.

Destruction - That is, they "cause" the destruction or the ruin of the reputation, happiness, and peace of others.

Misery - Calamity, ruin.

In their ways - Wherever they go. This is a striking description not only of the wicked then, but of all times. The tendency of their conduct is to destroy the virtue, happiness, and peace of all with whom they come in contact.