What two nations was at the head of axis power and europe

Germany, Italy and Japan because the alliance was began in 1936. In Oct. of 1936 Germany and Italy signed a friendship treaty

The major Axis Powers were Germany, Italy, and Japan.

Explanation:

The alliance began to form in 1936. First, on October 15, 1936 Germany and Italy signed a friendship treaty that formed the Rome-German Axis. It was after this treaty that Italian dictator Benito Mussolini used the term Axis to refer to their alliance.