As of the sixteenth century, Europeans had generally built up a greater immunity to smallpox than had the Native Americans. true or false

True

Explanation:

In 1520 a smallpox epidemic fell on Tenochtitlan, being a determining factor for its conquest, claiming the lives of millions of indigenous people according to historians. Many Aztecs succumbed to smallpox that brought the arrival of Europeans. Throughout the 16th century, viral diseases such as smallpox sowed death among indigenous people in territories that are now part of countries such as Colombia, Ecuador, Peru, Bolivia.