Why did animosity develop between American Indians and Spanish missionaries in Georgia?

The reason why animosity develop between American Indians and Spanish missionaries in Georgia:

There was great enmity and hostility between American Indians and the Spanish missionaries because these missionaries were built on the barrier islands on the coast of Georgia to convert the Americans into the catholic religion who were a part of Christianity.

With this Spanish could rule the region and make Indian Americans it's colony very easily and reap benefits of trading more and could explore further more in that region of Georgia.