The Eighteenth Amendment to the U. S. Constitution restricted which of the following psychoactive drugs?

A. heroin and other opiates

B. cocaine

C. tobacco

D. alcohol

Prohibited manufacturing or sale of alcohol in the US. AKA prohibition

The correct answer is the option D.

Explanation: This Amendment established the prohibition of "intoxicating liquors" in the United States. The amendment was proposed by Congress on December 18, 1917, and was ratified by the requisite number of states on January 16, 1919. The Eighteenth Amendment was repealed by the Twenty-first Amendment on December 5, 1933.