The fertile crescent refers to

the boomerang shaped crescent in the middle east that was the home to some of the earliest human civilizations.

Answer: the Fertile Crescent is often referred to as the Cradle of Civilization

Explanation: The Fertile Crescent is the boomerang-shaped region of the Middle East that was home to some of the earliest human civilizations. Also known as the "Cradle of Civilization," this area was the birthplace of a number of technological innovations, including writing, the wheel, agriculture, and the use of irrigation