The major reason Napoleon invasion of Russia failed was because

They werent used to the cold or ready for it

The major reason Napoleon's invasion of Russia failed was because he attacked at the wrong time.

Granted, summer is generally the time used to start invasions against cold-weather countries (as seen by the invasion of France and Germany in their respective times). However, many of them did not think of a long-term fight, and were generally tied up in the western-half of Russia, before being beaten back by weather, shortages, and the Russians.

~Rise Above the Ordinary