Which cultural difference was the major source of conflict between native Americans and Europeans

The major cultural difference that drove to frequent conflicts between Native Americans and Europeans was the belief for american Natives that the Mother Earth and land were sacred. They respected, and claimed they had a relationship of spirituality between them and all that comes from the Mother Earth. Land and natural resources were a blessing and gift from God. On the other hand, to the European cultures, land was a matter related to property, business, wealthiness, productivity, and power. For the majority of the Europeans, the Natives were wasting an exceptional opportunity and land could be traded and accumulated to generate income for their families, communities, and government.