Why did the western indian confederacy fail its effort to limit white settlement west of the appalachians?

There were several reasons which lead to failure of western Indian Confederacy to limit white settlement west of the Appalachians. Firstly we see the settlement was open and there were large white settlers in eastern states. The increasing agricultural economy increased white settlements in the region. The US government also adopted the policies of treaty, trickery and warfare to acquire the Indian lands and increase white settlement in the region. On the other hand the Indians lacked enough weapons and army which also failed them in their efforts to limit white settlement west of Appalachians.