How did the fact that the safavids were shiite muslims affect relations with the ottomans?

The Safavid Empire's religion was Shi'a Islam and all other religions, and forms of Islam were prohibited.

For over a century the Ottoman Empire and Safavid Persia fought over the control of the South Caucasus and Mesopotamia and dogmatic disputes: the Ottomans were Sunnis and believed the Shia Muslims of the Qizilbash sect were heretics.

Religious differences increased conflict between the two empires because each was composed of a different sect of Islam.