What cultures existed in the west before the settlers came to stake their claim upon the land?

There were multiple cultures that existed in the west before settlers from Europe came in and took over their land, and some of the most advanced and most recognizable are:

- Mississippi culture; it was the most advanced culture in North America, located alongside the Mississippi River in the United States.

- Aztec culture; it was the most advanced and strongest culture in Central America, located in the southern half of Mexico, Belize and Guatemala.

- Inca culture; it was the most advanced culture in South America, it was spread out on mostly on the territories of Peru, Bolivia, and Ecuador.