How would you place into perspective Jefferson's Louisiana Purchase and his vision of Republican Simplicity. Do they make sense or are they at odds?

They make sense because Jefferson was a Strict constructionist and didnt know if the Lousiana purchase would be Constitutional ... But he wanted to expand the growing nation.

Jefferson's purchase of the Louisiana territory from France was clearly at odds with the limits of presidential power that he, himself, argued for. Jefferson would have had to wait for a constitutional amendment in order to reconcile the purchase with his philosophy on states' rights.