The Louisiana purchase led directly to what?

a. Lewis and Clark expedition.

b. Treaty of Greenville.

c. War of 1812

d. Trail of Tears.

A. The Lewis and Clark expedition

President Thomas Jefferson sent Merriweather Lewis and William Clark on an expedition to explore the Louisiana Purchase that more the doubled the size of the United States.

I would have to say A) Lewis and Clarke expedition because Lewis and Clarke did explore the Louisiana Territory, The Treaty of Greenville happened before the purchase, and the other 2 had different causes.