When 100 mL of an aqueous solution containing 1.0 g of caffeine is extracted with 10 mL of chloroform at room temperature, 0.5 g of caffeine is transferred to the chloroform layer. Calculate the distribution coefficient of caffeine between chloroform and water at room temperature.

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Mathematics

Kristian

31 December, 11:35

When 100 mL of an aqueous solution containing 1.0 g of caffeine is extracted with 10 mL of chloroform at room temperature, 0.5 g of caffeine is transferred to the chloroform layer. Calculate the distribution coefficient of caffeine between chloroform and water at room temperature.

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Olivia Espinoza · Answer 1

The distri bution coefficient is simply the ratio of the concentrations of the solute in the two solvents.

In this case there is 0.5g of caffeine in 10 ml of chloroform and 0.5 g of caffeine in 100ml of water.

The ratio is 0.5/10 : 0.5/100 = 0.05 : 0.005 = 10 : 1