What effect did Hernando de Soto's expedition in Georgia have on Native American's there? it caused a mass migration of Native Americans from Georgia it began a long-term trading relationship with Native Americans it inspired Native Americans to join the Spanish mission system it brought illnesses that caused Native Americans population loss

After de Soto's expedition through the Southeast, including Georgia, the Native American population decreased rapidly due to exposure to European diseases for which Native Americans had no immunity. One reason for this is that the Spaniards brought pigs with them from Spain (as a food source, and to trade), and the pigs carried viruses and bacteria for influenza, tuberculosis, and other diseases. Even after the Spaniards had passed by, escaped pigs transmitted those diseases to Native Americans and to the deer and turkeys that they hunted.

The answer to this question is: A) it caused a mass migration of Native Americans from Georgia

Hernando de soto's forces were the first european troops that the natives ever seen, so they felt really bewildered when they first see De Soto's men.

After that, De Soto started to make conquests among this region which cause the native Americans to move out of this place in search of safety.