Given these processes: 1. Chondrocytes die 2. Cartilage matrix calcifies. 3. Chondrocytes hypertrophy. 4. Osteoblasts deposit bone. 5. Blood vessels grow into lacunae. Which sequence best represents the order in which they occur during endochondral bone formation?

The sequence that best represents the numbering or ordering of endochondral bone formation are

3 - chondrocytes hypertrophy

2 - cartilage matrix classifies

1 - chondrocytes die

5 - blood vessel grow into lacunae

Explanation:

The sequence that best represents the numbering or ordering of endochondral bone formation are

3 - chondrocytes hypertrophy

2 - cartilage matrix classifies

1 - chondrocytes die

5 - blood vessel grow into lacunae

Periosteal blood arteries invade calcified cartilage which induces osteoblasts and osteoclasts

4 - osteoblasts deposit bone

Osteoblasts accumulate bone on the calcified cartilage layer considered the key center of ossification.