Identify and explain one major difference between the way the House of Representatives and the Senate operates.

Introduction of bills for raising revenue.

Explanation:

The Origination Clause, also known as the Revenue Clause, Article I, Section 7, Clause 1 of the United States Constitution states that all bills for raising revenue must be proposed and initiated in the House of Representatives and then send it to the Senate for approval.

This is one of the major difference between the House of Representatives and the Senate. Bills relating to methods for raising money like taxes, customs duties, and tariffs, etc. can be initiated in the House of Representatives only.