Mary Hanson, a 2-year old, was brought to the doctor's office by her mother after she discovered two swollen and painful lumps in Mary's groin. Staphylococcus aureus was cultured from phagocytic cells obtained from the affected lesions and granulomas were noted. Additional tests revealed that neutrophils from Mary do not activate a respiratory burst after phagocytosis. The most likely protein defect would be

Question

Social Studies

Audrina Carter

7 March, 14:17

Mary Hanson, a 2-year old, was brought to the doctor's office by her mother after she discovered two swollen and painful lumps in Mary's groin. Staphylococcus aureus was cultured from phagocytic cells obtained from the affected lesions and granulomas were noted. Additional tests revealed that neutrophils from Mary do not activate a respiratory burst after phagocytosis. The most likely protein defect would be

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Ireland · Answer 1

NADPH oxidase subunit

Explanation:

This can be present throughout the plasma membrane as well as in the phagosome templates utilized by blood cells of neutrophils to absorb bacteria and viruses. In normal circumstances, the NADPH oxidase complex is dormant, but activated during respiratory burst to assemble in the membranes. The NADPH oxidase activated produces superoxide that has functions in animal immune reaction and plant sensing.