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River has tributaries that come from both the Appalachian and Cordillera Mountains.

The correct answer to this open question is the following.

The Roanoke River has tributaries that come from both the Appalachian and Cordillera Mountains.

The Roanoke River runs from the south part of the state of Virginia to the northeastern region of the state of North Carolina. It is one of the most important rivers in what is known as the coastal plain, next to the Appalachian Mountains, with its more than 400 miles. Many Native American Indians tribes lived along the banks of the Roanoke River when the first English colonists arrived at the North American territory in the 1600s.