How did involvement with Europeans in this region change how American Indian there lived

The europeans came and swiped american indiands out of their region such as the Cherokee which lived in Georgia, Tennessee, NC, SC, Kentucky, Alabama, Virginia And west virginia, Than the smallpox came and weakend most of the tribes It soon became and epicdemic through all of america. After the epidemic came the europeans and made a deal with the cherokee which was a trick to take them out of their land, So the cherokee's where evicted and thus starting the Trail of Tears.