List of major trouble is that Industries faced in the Great Depression

Lack of credit - banks didn't have money to lend to business to fund projects or expand

the dust bowl messed up travel in the midwest, so especially building train tracks there or roads would have been difficult

no one bought their products or services.

The Dust Bowl, stock market crash, not enough food / water, overpopulation, drought, movement west, taxes bot being payed, loans