What major city is the south in south america

I wonder if there were any options, or you just need an example?

The very south of the continent doesn't have many major cities. For example, Ushuaia in Argentina has only 60 thousand inhabitants. Punta Arenas in Chile is a bid bigger, with 100 000.

The really big cities are almost in the middle of the continent: Santiago de Chile, Montevide and Buenos Aires.