An important step in the evolution of true cells from macromolecular vesicles was the evolution of

self-replicating molecules

organic molecules

covalent bonding

hydrogen bonding

The correct option is A.

Scientist believed that true cells evolved from vesicles that contained self replicating RNA molecules. These molecules grew, divided and passed their RNA molecules to their daughters. Vesicles refers to fluid field compartments that are bounded by membrane like structures.