Considering the final steps in cholesterol biosynthesis, when squalene is eventually converted to lanosterol, which of the following statements is wrong? a. The action of squalene monooxygenase oxidizes C14 of the squalene chain, forming an epoxideb. Squalene is joined at carbons 1 and 30 to form the fused ring structure of sterolsc. All of the sterols have three fused rings (the steroid nucleus) and are alcohols with a hydroxyl group at carbon C3d. I Squalene monooxygenase uses reduced flavin nucleotides, such as FAD (2H), as the cosubstrate in the reactione. Squalene monooxygenase is considered a mixed function oxidase because it catalyzes a reaction in which only one of the oxygen atoms of O2 is incorporated into the organic substrate

Among all the options 4 options are wrong.

Wrong options:

a. The action of squalene monooxygenase oxidizes C14 of the squalene chain, forming an epoxide

b. Squalene is joined at carbons 1 and 30 to form the fused ring structure of sterols

c. All of the sterols have three fused rings (the steroid nucleus) and are alcohols with a hydroxyl group at carbon C3

d. I Squalene monooxygenase uses reduced flavin nucleotides, such as FAD (2H), as the cosubstrate in the reaction

Correct Option:

e. Squalene monooxygenase is considered a mixed function oxidase because it catalyzes a reaction in which only one of the oxygen atoms of O2 is incorporated into the organic substrate

Reference Book:

Marks' Basic Medical Biochemistry

Chapter 34

Cholesterol Absorption, Synthesis, Metabolism, and Fate