Untreated diabetes mellitus can lead to a condition in which the blood is more acidic than normal. Name two organ systems that play the largest role in compensating for acid-base imbalances.

The two organ systems in the body that play the largest role in compensating for acid-base imbalances are the pulmonary and renal systems.

Explanation:

i. The renal system compensate for acid-base imbalances by reabsorbing bicarbonate and excreting fixed acids. kidney excretes or reabsorbs these substances during disease state which affect pH.

ii. The pulmonary system compensate for pH by using carbon dioxide; expiration removes carbon dioxide from the body which is released to the environment. Carbon dioxide in the body forms carbonic acid when combine with water. The amount of carbon dioxide expired can cause pH to increase or decrease. The respiratory system's effect on metabolic pH disturbances occurs in minutes to hours.