Give two reasonsthat may account for the continuous firing of a

PostsynapticNeuron.

1. Continuous diffusion of negatively charged ions into the postsynaptic neurons, which leads to continuous reversal of charges (hyperpolarization) and therefore continuous firing of action potential

2. Inhibition of hydrolytic enzymes e. g (acetycholinesterase) that metabolize activities of cholinergic neurotransmitters e, g acetycholine at post synaptic cleft. leading to firing of action potential.

Explanation:

Neuron whose dendrites transmits action potential to the neuromuscular junction is called presynaptic neuron. While neuron that transmit action potential away from the neuronal synaptic junction, or from the neuromuscular junction to the cell body of adjacent neuron or to effectors (gland and muscles) are called post synaptic neuron.

The more negatively charged ions that diffused into the post synsptic neuron, the more depolarization, and the greater the frequency of action potential produced

The inhibition of activities of hydrolytic enzyme which metabolize cholinergic neurotransmitter leads to continuous excitatory activities of cholinergic neurotransmitters on the receptors at the postsynaptic neuron, and the more action potential