Which condition might interfere with a breeder's attempt to predict the change in a trait over many generations based on their knowledge of the trait's heritability?

A change in genetic variance Natural selection New genetic mutations Linkage disequilibrium

Explanation:

Change in genetic variance:

Polymorphisms : Variation between individuals in a population (within species). Substitutions : Fixed variation between individuals of species (between species)

Natural Selection:

Those organisms best adapted to their environment have a better chance of surviving and reproducing.

New genetic mutations:

New permanent change in the base sequence of DNA.

Linkage disequilibrium:

Non-random assortment of allelles at 2 or more loci. The closer the markers the stronger the LD, since recombination will have occured at a low rate.

All these conditions interfere with a breeder's attempt to predict the change in a trait over many generations based on their knowledge of the trait's heritability.