How would signaling be affected if a mutation caused a g protein to replace gdp with gtp on its own without needing to be activated by the g protein-coupled receptor?

Question

Biology

Rodrigo Choi

6 August, 20:00

How would signaling be affected if a mutation caused a g protein to replace gdp with gtp on its own without needing to be activated by the g protein-coupled receptor?

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Answers (1)

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Kristina Mendoza · Answer 1

This mutation will produce a conformational change capable of maintaining the receptor continuously in its activated mode

Explanation:

G proteins are inactive when guanosine diphosphate (GDP) is bound, while they are active when guanosine triphosphate (GTP) is bound