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23 December, 13:36

How many atp equivalents are consumed in the conversion of each of the following to a glucosyl residue in glycogen?

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  1. 23 December, 14:15
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    Answer;

    Dihydroxyacetone phosphate - 1

    Fructose-1,6-bisphosphate - 1

    Pyruvate - 13

    G-6-P - 1

    Explanation;

    1) Dihydroxyacetone phosphate = 1

    G1P + GTP - -> UDPG + PPi two P is equivalent to 2 ATP - -->2 ADP + Pi) Therefore, two ATP equivalents - but UDP is the product and only one P needed

    2 DHAP - -> F1,6-BP - ->F6P - -> G6P - ->G1P - ->UDPG - -> glucosyl residue

    2) Fructose 1,6-bisphosphate = 1

    3) Pyruvate = 13

    2 pyr + 2 ATP - -> 2 OAA

    2 OAA + 2 GTP - -> 2 PEP

    2 PEP - -> 2 2PG - -> 2 3PG

    2 3PG + 2 ATP - -> 2 1,3 BPG

    2 1,3 BPG + 2 NADH - -> 2 G3P

    2 NADH = 6 ATP

    2 G3P - -> DHP + G3P - -> FDP - - > F6P + P

    F6P - -> G6P - -> G1P

    G1P + UTP - -> UDPG + PP

    4) Glucose-6-phosphate = 1

    G6P - ->G1P G1P + UTP - -> UDP-GLC + 2 Pi

    UDP-Glc + glycogen - -> glycogen + 1 Glc
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