Was the first nonsedating antihistamine drug; however, it has been taken off the market due to adverse effects when combined with certain other drugs.

Terfenadine was the first nonsedating antihistamine drug that was taken off the market due to adverse effects when combined with certain other drugs. Terfenadine was introduce to the market on 1985 by Hoechst Marion and Sanofi-Aventis which was formerly known as Roussel. It was in the market with different brand names such as Teldane in Australia, Triludan in the United Kingdom, and Seldane in the United States. It was taken off of the market on 1990 and was replaced by fexofenadine because serious cases of ventricular arrhythmias (abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles) was diagnosed among those people whose taking the drug when combined to other drug with macrolide antibiotic and ketoconazole.