A 2-day-old newborn male is diagnosed with congenital lactic acidosis because of a defective electron transport protein. This deficiency leads to a decrease in the rate at which NADH and FADH2 can be oxidized to produce ATP using oxidative phosphorylation and results in an increase in cytosolic AMP. Under these conditions which glycolytic enzyme would be stimulated?

Question

Chemistry

Ace Foley

10 February, 15:44

A 2-day-old newborn male is diagnosed with congenital lactic acidosis because of a defective electron transport protein. This deficiency leads to a decrease in the rate at which NADH and FADH2 can be oxidized to produce ATP using oxidative phosphorylation and results in an increase in cytosolic AMP. Under these conditions which glycolytic enzyme would be stimulated?

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Answers (1)

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Holden Ashley · Answer 1

Phosphofructokinase-1

Explanation:

Phosphofructokinase-1 is the enzyme which is responsible in controlling glycolysis pathway when the ratio of ATP/AMP is altered.

High levels of AMP and low levels of ATP in the body stimulates activity of the enzyme, Phosphofructokinase-1. Thus, the process of glycolysis is stimulated when the energy charge falls.

The enzyme is inhibited by citrate, PEP and ATP.