Which two Latin American countries seem to have the largest drug trafficking problem?

Mexico and Columbia

Explanation:

Mexico and Columbia drug level of trafficking has been a problem to this nations because it has grown into cartels who have equipped themselves with resources, fire power, and connections in the government circle to slow down their activities.

Drugs worth $39b where sold between these drug countries in a year. The arrest and rearrest of Mexican drug lord Elshapo Guzman in Guatemala who later break the jail but was later rearrested in Mexico shows how this cartel are powerful.