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28 February, 09:06

I am trying to determine reactants going into the electron transport chain. Is this right?

Glycolysis: 2 NADH

Pyruvate oxidation: 2 NADH (in total from both pyruvates)

Krebs cycle: 6 NADH (in total) + 2 FADH^2

In total, the reactants are: 10 NADH and 2 FADH^2

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Answers (1)
  1. 28 February, 10:14
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    Yes, this is correct.

    Explanation:

    In each glycolytic pathway, glyceraldehyde 3-phosphate dehydrogenase produces 1 molecules of NADH as a result of reduction of NAD+. Pyruvate dehydrogenase converts pyruvate to Acetyl CoA producing 1 molecule of NADH per pyruvate oxidized. In Kreb's cycle, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, and malate dehydrogenase reactions produce 1 molecule of NADH each. Furthermore, succinate dehydrogenase reaction produces a single molecule of FADH2 per FAD reduced. Since, we began with 2 molecules of glyceraldehyde 3-phosphate, we multiply the above figures by 2 and get a total of 10 NADH and 2 FADH2.
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